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Ritonavir or lopinavir/ritonavir enormously improve plasma concentrations of oxycodone in healthy human volunteers as a result of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin considerably lessens plasma concentrations of oxycodone on account of powerful induction of CYP3A4.An extensive affected person heritage need to be taken to doc concomitant